Test Catalog

Test

Code
L018
Name
PHOSPHATIDYLETHANOL (PETH), WHOLE BLOOD QUANT
Description

Alternative Names: 1,2-dioleoyl-sn-glycero-3-phosphoethanol , 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanol
Includes: PEth 16:0/18:2 (PLPEth), PEth 16:0/18:1 (POPEth), EER PEth, PEth Interpretation
Sample Type: Whole Blood
Preferred Container: K2 or K3 EDTA (Lavender Top) Tube
Alternate Container: Lithium Heparin (Green Top) Tube, Potassium Oxalate (Gray Top) Tube
Sample Volume: 1.0 mL
Minimum Volume: 0.5 mL
Handling Instructions: Transport 1 mL whole blood. (Min: 0.5 mL)
Transport Temperature: Refrigerated
Specimen Stability: Refrigerated: 2 weeks; Frozen: 1 month (-20°C)
Testing Frequency: Sunday – Saturday
Expected Turn Around Time: 2-5 days
Testing Facility: Ref Lab ARUP
CPT Codes: 80321
Note: Interpretive Data: Phosphatidylethanol (PEth) is a group of phospholipids formed in the presence of ethanol, phospholipase D and phosphatidylcholine. PEth is known to be a direct alcohol biomarker. The predominant PEth homologues are PEth 16:0/18:1 (POPEth) and PEth 16:0/18:2 (PLPEth), which account for 37-46% and 26-28% of the total PEth homologues, respectively. PEth is incorporated into the phospholipid membrane of red blood cells and has a general half-life of 4 – 10 days and a window of detection of 2 – 4 weeks. However, the window of detection is longer in individuals who chronically or excessively consume alcohol. Serial monitoring of PEth may be helpful in monitoring alcohol abstinence over time. PEth results should be interpreted in the context of the patient’s clinical and behavioral history. Patients with advanced liver disease may have falsely elevated PEth concentrations (Nguyen VL et al 2018, Alcoholism Clinical & Experimental Research)