Also known as: CYP2D6, CYTOCHROME P450 2D6 GENOTYPE, CYT2D6, U496
Test Contains (LOINC): CYP2D6 Specimen (31208-2), CYP2D6 Genotype (40425-1),2D6GENO Interpretation (50398-7)
Sample Type: Whole Blood or Saliva
Preferred Container: Whole Blood: EDTA (Lavender Top) Tube, ACD Solution A (Yellow Top) Tube or ACD Solutio B (Yellow Top) Tube. Saliva: Collection Device by Spectrum Solutions, LLC
Sample Volume: Whole Blood: 3.0 mL
Minimal Sample Volume: Whole Blood: 1.0 mL
Transport 3 mL whole blood OR Saliva Collection Device.
Client Transport Temperature: Refrigerated
Specimen Stability: Collection to initiation of testing: Ambient: 72 hours; Refrigerated: 1 week; Frozen: 1 month
Unsuitable Specimen: Plasma or serum. Specimens collected in sodium heparin or lithium heparin. Frozen specimens in glass collection tubes.
Expected Turn Around: 6 – 11 Days. If reflexed, 5 – 7 additional days are required for LR-PCR and sequencing.
Responsible Dept: Reference Lab
Referral Lab Code: 3001513
CPT: 81226; if reflexed, add 81479
Methodology: Polymerase Chain Reaction/Fluorescence Monitoring
Notes: Whole blood is the preferred specimen type. Saliva samples that yield inadequate DNA quality and/or quantity will be reported as inconclusive if test performance does not meet laboratory-determined criteria for reporting. Saliva is only validated for the OpenArray and CNV portions of testing and not the long-range PCR/duplication testing. Long-range PCR/duplication testing will not be performed for saliva samples. If long-range PCR/duplication testing is performed, additional charges will apply. Approximately less than 5% of samples require 2D6 copy number determination.